Sofosbuvir Tablets

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Therapeutic Indication

Chronic hepatitis C virus (HCV) infection (genotypes 1–6)
Used in combination with other antivirals (e.g., Ledipasvir, Velpatasvir)
Patients with compensated cirrhosis
Post-liver transplant HCV recurrence
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Fexofenadine

Tablet

Sofosbuvir is a direct-acting antiviral agent used in the treatment of chronic hepatitis C virus (HCV) infection. It is a nucleotide analog inhibitor of the HCV NS5B RNA-dependent RNA polymerase, essential for viral replication.

Speciality Hepatology | Infectious Diseases | Internal Medicine
Tags Hepatitis C | Antiviral | NS5B Polymerase Inhibitor | Direct-acting Antiviral
Strength
  • 400 mg
Packing Size
  • 10 Tablets

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Mechanism

Sofosbuvir is metabolized to the active triphosphate form, which inhibits the HCV NS5B RNA-dependent RNA polymerase. This prevents viral RNA replication and reduces viral load.

Pharmacokinetics

  • Absorption: Rapidly absorbed; peak plasma levels in 0.5–2 hrs.
  • Distribution: ~61–65% protein bound.
  • Metabolism: Hepatic metabolism to active triphosphate.
  • Excretion: Renal excretion of metabolites.
  • Half-life: ~0.4 hrs (parent drug); active metabolite longer.
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Side Effects

  • Fatigue
  • Headache
  • Nausea
  • Insomnia
  • Rare: Bradycardia (with amiodarone co-administration)

Contraindication

  • Hypersensitivity to Sofosbuvir
  • Severe renal impairment (use cautiously)
  • Not recommended as monotherapy

Interaction

  • Amiodarone ↑ risk of severe bradycardia
  • Rifampin and St. John’s Wort ↓ sofosbuvir levels
  • Other antivirals used in combination therapy

Warning and Precautions

  • Always use in combination with other antivirals
  • Monitor liver function during therapy
  • Use cautiously in renal impairment

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.